M.Sc. (1987) University of Amsterdam (UVA)
Ph.D. (1992) Free University Amsterdam (VUA)
Professor, University of New Mexico (UNM)
CETI, Department of Biology MSC03 2020,
2428 Castetter Hall
University of New Mexico, Albuquerque, 87131 NM USA
Tel (505) 277 2743 (o); Fax (505) 277 0304,
coenadem@unm.edu
Member of the
Biomphalaria glabrata genome initiative
Member of the Center for Evolutionary
and Theoretical Immunology (CETI)
The Adema Lab
Current focus
Molecular characterization of gene
expression profiles during anti-pathogen responses of Biomphalaria glabrata;
Function, diversity, expression of fibrinogen-related proteins (FREPs) produced
by Biomphalaria glabrata and other molluscs, Biomphalaria glabrata
genome annotation, Onchocerca lupi in NM, Comparative immunogenomics
of Panpulmonata, Gastropod mitogenomics.
TECHNIQUES USED
Parasitology: in vitro
culture of Trichomonas vaginalis (flagellate protozoan), maintenance
of life cycles and in vitro culture of Acantocheilonema (previously Dipetalonema)
viteae (filarial nematode), Trichobilharzia ocellata, Echinostoma
paraensei, and Schistosoma mansoni (digenetic trematodes), maintenance
of several snail species. Field collection of aquatic snails, testing for digenean
infection, Field collection of bloodfeeding arthropods.
Histology: cryostat and
parrafin sections
Cell biology: monolayers,
phagocytosis, cytochemical assays for lysozymal enzymes, antibody- and lectin-recognized
surface epitopes, intravacuole pH and ROIs, spectrophotometrical assays for
ROIs, luminol dependent chemiluminescence (LDCL), inhibition of NADPH-oxidase,
development of anti-clumping buffer, density gradient cell separations, cell
free ROI cytotoxicity assays, time-lapse video microscopy, confocal microscopy,
hemocyte rounding assays, hemocyte bactericidal assay.
Serology: immuno-absorption,
immunizations, for antisera and monoclonal antibody production, ELISA, IFAT,
western blotting.
Protein biochemistry: size exclusion chromatography, SDS- and native PAGE, blotting,
preparation of samples for amino acid sequencing, protein biotinylation,
, proteomics (sample preparation for MS/tandem MS and computational analysis).
Molecular biology: (CTAB) genomic DNA extractions, high molecular weight DNA extraction,
alkaline lysis (and kit) plasmid DNA extractions, restriction digests,
(m)RNA extractions, DNA and RNA gel electrophoresis, isotope/biotin labeling
of DNA and anti-sense RNA probes, Southern blotting, northern blotting, in-situ
hybridization, PCR primer design, PCR, LD-PCR, RT-PCR, qPCR, (TA-) cloning,
construction of genomic and cDNA libraries, cycle sequencing, EST-techniques
(EST; ORESTES; SSH-ESTs), marathon and gene walker protocols, EZ::TN mediated
sequencing of constructs, BAC DNA extraction, subcloning and sequencing, oligo
microarray design and probing, genome assembly, annotation, 454-, Illumina-,
MinION- NGS.
Software: (pc-based) dnasis,
chromas, blast, entrez, expasy motifs, image analysis, sequencher, genedoc,
bioedit, RNAviz, Newbler, Genespring, Artemis, WebApollo, Galaxy, Mitobim, Mitos.
BIRTH
27th July 1963, San Jose, California, USA
USA and Dutch (dual) nationalities
EDUCATION
1984 BS Medical Biology
University of Amsterdam (UVA), The Netherlands
1987 MS Medical Biology, Cum Laude
University of Amsterdam (UVA), The Netherlands
Medical Parasitology: Demonstration of circulating antigens
in filariasis.
subsidiaries
a) Molecular Cell Pathology: The cloning of single
copy DNA from human chromosome 14.
b) Teaching Degree, general biology.
1992 PhD
Free University (VU) Amsterdam, The Netherlands
Dept. of Medical Microbiology and Parasitology,
Faculty of Medicine, Feb 1988 - July 1992
Dissertation: Haemocyte-mediated cytotoxicity in the pond snail
Lymnaea stagnalis,
intermediate host of Trichobilharzia ocellata
POSITIONS
Department of Biology, University of New Mexico (UNM)
Post-doc (Biology, UNM) with Dr ES Loker(1993-1999)
Research Assistant Professor (1997-2003)
Research Associate Professor (2003-2009)
Associate Professor (2010-2012)
Associate Professor tenured (2012-2017)
Associate Director CETI-CEC Controlled Environment Core (2012-)
Professor (2017-)
Visiting sabbatical scientist (Feb 2018) EAWAG, ETH Zurich, Switzerland.
Visiting sabbatical scientist (Mar-Apr 2018) Biology, Vrije Universiteit Amsterdam,
the Netherlands.
GRANTS
Dutch Foundation for Scientific Research (NWO)
Three week working visit to URPIGM/IFREMER,
La Tremblade, France. Subject: Comparative gastropod/bivalve
immunobiology Feb-Mar 1991
European Community (EC)Human Resources Program
personal application for a 2 year post-doc position
with IFREMER, Montpellier, France. Subject: Bactericidal activity
in the bivalve Mytilus edulis
Post-doc mentor Dr P Roch Grant was declined as it was
awarded only after CM Adema had accepted
a post-doc position at UNM, Albuquerque, NM, USA 1993
National Science Foundation (NSF) MCB 9974930,
Principal investigator (PI)
Biology UNM, Albuquerque, NM, USA. Subject: Function and diversity
of molluscan FREPs
1 August 1999-2002.
National Science Foundation (NSF) supplement
for MCB 9974930, Research experience for undergraduate (REU),
10 weeks student stipend, summer 2000.
National Institutes of Health (NIH), NIAID RO1 AI052363,
Principal investigator (PI)
Biology UNM, Albuquerque, NM, USA. Subject: Anti-pathogen-responses
in Biomphalaria glabrata
April 2003-2011.
University of Wyoming/National Park Service
(UW/NPS), Co-principal investigator (co-PI) with Dr RS Seville (UW Casper),
UW/NPS Research Station, Jackson WY, USA. Subject: Parasite infection status
of Potamopyrgus antipodarum
July-August 2005.
National Institutes of Health (NIH), NIAID RO1
AI024340, Co-Principal investigator (PI: Dr ES Loker)
Biology UNM, Albuquerque, NM,
USA. Subject: Biology of trematode-snail associations
March 2006-2009.
IdEA NCRR, P20RR018754, COBRE Center for Theoretical
and Evolutionary Immunology (PI: Dr ES Loker)
Biology UNM (5 year grant). Adema is leader of subproject entitled: Schistosomiasis
in snails; basis for long term production of cercariae.
2009-2012.
Research Allocation Committee (RAC), Small Grant
Award, Principal investigator (PI),
Biology UNM, Albuquerque, NM,
USA. Subject: Canid ocular filariaisis in NM.
January 2013 – July 2014.
The Bill & Melinda Gates Foundation, Grand
Challenges Exploration, New Approaches for Detection, Treatment, and Control
of Selected Neglected Tropical Diseases
Primary Investigator (PI), Biology UNM, Albuquerque, NM, USA. Subject: Sentinel
System for Detection of Schistosome Transmission.
November 2013 - May 2015
CETI Waiver for NextGen Sequencing
Primary Investigator (PI), Biology UNM, Albuquerque, NM, USA
Subject Genomic sequencing of two species of land snails
May 2015, direct.
CETI Waiver for NextGen Sequencing
Primary Investigator (PI), Biology UNM, Albuquerque, NM, USA
Subject Transcriptomic profiling of lab and field isolates of Physella acuta
Dec 2015, direct.
Teaching Allocation Grant (TAG), Teaching Allocations
Subcommittee UNM
Primary Instructor, Biology UNM, Albuquerque, NM, USA
Subject: Genome sequencing in a lecture/lab class, hands-on training in modern
Next Generation Sequencing and computational bioinformatics
Fall 2016, $1,000.--
Fall 2018, $2,826.--
TEACHING AT UNM (University of New Mexico)
Courses taught
Introductory Parasitology, 1997
Comparative Immunology, 1997
Molecular Cell Biology 2 (426/526) 2002
Laboratory Methods in Molecular Biology (446/546) Fall 2006, 2008,
2009, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
Parasitology(482L/582L) Spring 2007, 2009, 2011, 2014
Molecular and Cell Biology (201) 2007F, 2008S, 2010S, 2012S, 2013S,
2015S, 2016S
Invertebrate Immunology (401) 2017S
Invertebrate Immunoparasitology (402/502), 2011F, 2012SF, 2013SF,
2014SF, 2015SF, 2016SF, 2017SF, 2018F, 2019SF
Graduate Students
Journey Nolan, MS Biology
UNM, 2011-2013
“Molecular Characterization of the snail Physella acuta”
.
Janeth
J Pena, PhD Biology UNM, 2011-2018
"Hemocyanin-like 1 protein, unique to planorbid snails, supports reproductive
output of Biomphalaria glabrata, vector of schistosomiasis"
Erin Watson, MS2 Biology UNM, 2015-2018
Jonathan
Schultz, PhD Biology UNM, 2013-2018
"Physella acuta, comparative immunology and evolutionary aspects of gastropod
immune function"
Kevin McQuirk, PhD Biology UNM, 2019-
Graduate Student Committees
PhD students
Pascale Leonard, Advisor Loker, Biology UNM, 1999-2001
Shibin Qui, Advisor Lane, Computer Science UNM, 2005-2006
Kiran Ambatipudi, Advisor Deane, Macquarie University, Sydney, Australia,
2007
Ramesh Devkota, Advisor Loker, Biology UNM, 2009-2015
Xin-Xin Wang, Advisor Miller, Biology UNM, 2010-2011
TyAnne Lovato, Advisor Cripps, Biology UNM, 2011-2014
Arinder Arora, Advisor Loker, Biology UNM, 2011-2015
Mattias Roth, Advisor Nair, Macquarie University, Sydney, Australia,
2012
Li-Jun Lu, Advisor Loker, Biology UNM, 2012-
Ali Sepahi, Advisor Salinas, Biology UNM, 2013-2018
Caitlin Babbitt, Advisor Loker, Biology UNM, 2017-
Teo Cereghetti, Advisor Seppala EAWAG, ETH-Zurich, Switzerland, 2018-
Cansu Cetin, Advisor Seppala EAWAG, ETH-Zurich, Switzerland, 2018-
Ms students
Andrew Lynch, Advisor Duszynski, Biology UNM, 2003-2004,
Noorus Sahar Abubucker, Advisor Lane, Computer Science UNM, 2004-2005
Michelle Archuleta, Advisor Cunningham, UNM Biology 2007-2008
Jason Marquardt, Advisor Bergthorsson, UNM Biology 2010-2012
Mentor of Post-baccalaureate Research and Education
Program (PREP) scholar
Journey Nolan, Biology, UNM, 2010-2011. The mitochondrial genome of
Physella acuta
Daniela Martinez, Biology, UNM, 2014-2015 Arthropod vectors
of avian malaria within Albuquerque
Supervision of Research Experience for Undergraduates
(REU) students
Biology, University of New Mexico (UNM), NM USA 1993-present
Sponsors: Howard Hughes Foundation and
Minority Biomedical Research Support (MBRS), 1993-1998, 2002-2004
National Science Foundation (REU), Jaime Reif, 2000-2001
Minority Access to Research careers (MARC), Steven Saenz, Gene discovery
in Biomphalaria glabrata, 2004-2005
Initiative for Minority Student Development (IMSD), Teresa Madrid,
FREP BAC sequencing, 2005-2006
Alliance for Minority Participation (AMP), Bria Riggens, FCM Hemogram
of Biomphalaria glabrata , 2013
Initiative for Minority Student Development (IMSD), Quan M. Huynh,
Arthropod vectors of parasites in city parks of Albuquerque NM, 2014-16
Undergraduate Problems 499/student volunteers,
Fall 2007, Tara Kraus and Casey Smith, Parasite infections of the Red
Shiner (Cyprinella lutrensis) in the Rio Grande
Spring and Fall 2009, Devaraj Aran, Hagit Salomon, Amanda Watson, Sequencing
of the mitochondrial genome of Echinostoma paraensei
Spring 2011, Zachary Weiss, Estivation in Biomphalaria glabrata
Fall 2011, Nathan Romero, Localizing genomic diversification in Biomphalaria
glabrata
Spring 2012, Thomas Valerio, Bioinformatics analysis of transcriptome
of Echinostoma paraensei
Fall 2012, Spring 2013, Karen A Davila, Onchocerca lupi,
filariasis of canids in New Mexico
Fall 2012, Niels K Winsor (551), Human Toxoplasmosis
Spring 2013, Amanda Elizabeth Fingado, Gene expression in Physella
acuta
Spring, Fall 2013, Cristin Jones, Onchocerca lupi, filariasis
of canids in New Mexico
Fall 2013, Audrey Melton, Onchocerca lupi, filariasis of canids
in New Mexico
Spring 2016, Bianca Myers, Hemocyanin-like sequences in snails
Spring 2016, Ian Keller, FREP diversity in Physella acuta
Summer 2017, Hannah Livesay, Onchocerca lupi, filariasis of canids
in New Mexico
Summer 2017, Zachary Fry, Onchocerca lupi, filariasis of canids
in New Mexico
Spring 2019, Jon Locke, (499), Complement evasion in Borrelia
spirochetes, published 2019, Antibiotics (Basel). 8. pii: E80. doi:
10.3390/antibiotics8020080.
Spring 2019, Vicente Sanchez, Stylommatophora, clade-specific mitogenome
primers
Spring 2019, Tryton Shelp, Onchocerca lupi epidemiology
AWARDS AND HONORS
Dutch Society for Parasitology (NVP)
~US$ 250, awarded twice, towards attendance and oral presentation
a) Joint Spring Meeting British, Belgian and Dutch Societies
for Parasitology,
Southampton UK 1989
b) Spring Meeting British Society for Parasitology, Symposium
Molluscs in Parasite
Life Cycles, Liverpool UK 1991
International Society for Developmental and Comparative
Immunology (ISDCI)
US$ 300 towards attendence and presentation,
Vth ISDCI conference Portland OR, USA (PhD-student category)
July 1991
JE Jurriaanse Foundation, Rotterdam, The Netherlands
~US$ 1000 towards completion of PhD dissertation June 1992
Keystone Symposia, US$ 500 for scientific merit
of poster (post-doc category)
Molecular Helminthology conference, Santa Fe NM, USA February
1996
10th Symposium on Schistosomiasis, Invited speaker, Belho Horizonte, Brazil, Sep 2005
President's symposium on Immunity in invertebrate
hosts of parasites, American Society of Parasitologists (ASP),
Invited speaker, Joint Meeting at ICOPA, Glasgow, Scotland, Aug 2006
11th Symposium on Schistosomiasis, Invited speaker, Salvador Bahia, Brazil, Sep 2008
26th ESCPBnew Congress, new European Society
for Comparative Physiology and Biochemistry,
Invited speaker for symposium Environmental stimuli and their impact on homeostasis
and gene regulation
Innsbruck, Austria, Sep 2009
14th Annual Biomedical and Comparative Immunology Symposium, Invited Plenary speaker, Judge student presentation, Florida International University, Miami FL, March 2012
13th Symposium on Schistosomiasis, Invited speaker, Belho Horizonte, Brazil, Sep 2012
Research group Ecologie et Evolution des Interactions
(2EI), Planning visit for collaborative research and Departmental Seminar, Université
de Perpignan, CNRS, Perpignan, France, Dec 2012.
Certificate of Reviewing Excellence awarded by Elsevier and the Editors of Journal
of Invertebrate Pathology, for contributions as a peer reviewer, selected by
the editors in recognition of high quality work. 2013
EAWAG (Aquatic Ecology), Invited seminar, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, Feb 2018.
Institut Sophia Agrobiotech (Insect Defense), Invited seminar, CNRS Nice Antipolis, France, March 2018.
Dieroecology (Ecological Science), Invited “Nature of Life” seminar, included a 1 hour Q&A with graduate students, Vrije Universiteit Amsterdam, The Netherlands April 2018 https://www.amsterdamecology.nl/nol-10-april-2018/.
15th Symposium on Schistosomiasis, Invited conference speaker, Rio de Janeiro, Brazil, Aug 2018.
Pearls of wisdom: synergising leadership and expertise in molluscan genomics, Theo Murphy international scientific meeting, Royal Society, Invited conference speaker, Buckinghamshire, UK, Sep 2019.
SCIENTIFIC SOCIETIES
American Society of Parasitologists (ASP)
International Society for Developmental and Comparative Immunology (ISDCI)
H-index 38, I-10-index 56 (Google Scholar: Sep
2019)
https://scholar.google.com/citations?user=YXcdRNwAAAAJ&hl=en
https://www.researchgate.net/profile/Coen_Adema
orcid.org/0000-0002-6250-5499
1) Adema CM, van Deutekom-Mulder EC, van der Knaap WPW, Meuleman EA, Sminia T (1991) Generation of oxygen radicals in hemocytes of the snail Lymnaea stagnalis in relation to the rate of phagocytosis. Developmental and Comparative Immunology 15:17-26.
2) Adema CM, van der Knaap WPW, Sminia T (1991) Molluscan hemocyte-mediated cytotoxicity: the role of reactive oxygen intermediates. Reviews in Aquatic Sciences 4:201-223.
3) Adema CM, Harris RA, van Deutekom-Mulder EC (1992) A comparative-study of hemocytes from 6 different snails: morphology and functional-aspects. Journal of Invertebrate Pathology 59:24-32.
4) Harris RA, Adema CM, van Deutekom-Mulder EC (1992) A comparative-study of hemocytes from 6 different snails : surface staining with lectins and monoclonal-antibodies. Comparative Haematology International 2:30-34.
5) Mohandas A, Adema CM, van der Knaap WPW, Sminia T (1992) The effect of hemolymph extraction on distribution of lysosomal-enzymes in Lymnaea stagnalis hemocytes: a cytochemical study. Comparative Haematology International 2:61-67.
6) van der Knaap WPW, Adema CM, Sminia T (1993) Invertebrate blood-cells : morphological and functional-aspects of the hemocytes in the pond snail Lymnaea stagnalis. Comparative Haematology International 3:20-26.
7) Fryer SE, Adema CM (1993) Manipulation of Biomphalaria glabrata (Say) (gastropoda, planorbidae) hemocytes in-vitro. Journal of Molluscan Studies 59:371-379.
8) Adema CM, van Deutekom-Mulder EC, van der Knaap WPW, Sminia T (1993) NADPH-oxidase activity : the probable source of reactive oxygen intermediate generation in hemocytes of the gastropod Lymnaea stagnalis. Journal of Leukocyte Biology 54:379-383.
9) Adema CM, Mohandas A, van der Knaap WPW, Sminia T (1994) Separation of Lymnaea stagnalis hemocytes by density gradient centrifugation. Developmental and Comparative Immunology 18:25-31.
10) Adema CM, van Deutekom-Mulder EC, van der Knaap WPW, Sminia T (1994) Schistosomicidal activities of Lymnaea stagnalis hemocytes: the role of oxygen radicals. Parasitology 109:479-485.
11) Nunez PE, Adema CM, de Jong-Brink M (1994) Modulation of the bacterial clearance activity of hemocytes from the fresh-water mollusk, Lymnaea stagnalis, by the avian schistosome, Trichobilharzia ocellata. Parasitology 109:299-310.
12) Adema CM, Arguello DF, Stricker SA, Loker ES (1994) A time-lapse study of interactions between Echinostoma paraensei intramolluscan larval stages and adherent hemocytes from Biomphalaria glabrata and Helix aspersa. Journal of Parasitology 80:719-727
13) Loker ES, Adema CM (1995) Schistosomes, echinostomes and snails: comparative immunobiology. Parasitology Today, 11:120-124
14) Hanelt B, van Schyndel D, Adema CM, Lewis LA, Loker ES (1996) The phylogenetic position of Rhopalura ophiocomae (orthonectida) based on 18S ribosomal DNA-sequence analysis. Molecular Biology and Evolution, 13:1187-1191
15) Hanelt B, Adema CM, Mansour MH, Loker ES (1997) Detection of Schistosoma mansoni in Biomphalaria using nested PCR. Journal of Parasitology 83:387-394
16) Adema CM, Loker ES (1997) Specificity and immunobiology of larval digenean-snail associations. In Advances in Trematode Biology, Eds Fried B, Graczyk TK, CRC Press, Boca Raton Florida, pp 230-263
17) Adema CM, Hertel LA, Loker ES (1997) Infection with Echinostoma paraensei (Digenea) induces parasite-reactive polypeptides in the hemolymph of the gastropod host Biomphalaria glabrata. In Parasite Effects on Host Physiology and Behavior, Ed Beckage N, Chapman Press New York, pp 77-99
18) Adema CM, Hertel LA, Miller RD, Loker ES (1997) A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection. Proceedings of the National Academy of Sciences USA 94: 8691-8696
19) Adema CM, Hertel LA, Loker ES (1999) Evidence from two planorbid snails of a complex and dedicated response to digenean (echinostome) infection. Parasitology 119:395-404.
20) Adema CM, Léonard PM, DeJong RJ, Day H, Edwards D, Burgett G, Hertel LA, Loker ES (2000) Analysis of messages expressed by Echinostoma paraensei miracidia and sporocysts, obtained by random EST sequencing. Journal of Parasitology 86:60-65.
21) Adema CM, Sapp KK, Hertel LA, Loker ES (2000) Immunobiology of the relationship of echinostomes with invertebrate hosts. In Echinostomes as Experimental Models for Biological Research, Eds Fried B, Graczyk TK, Kluwer Academic Publishers, Dortdrecht, The Netherlands, pp 149-174.
22) Léonard PM, Adema CM, Zhang S-M, Loker ES (2001) Structure of two FREP genes that encode IgSF and fibrinogen domains, with comments on diversity of the FREP gene family in the snail Biomphalaria glabrata. Gene 269:155-165.
23) DeJong RJ, Morgan JAT, Paraense WL, Pointier J-P, Amarista M, Ayeh-Kumi PFK, Babiker A, Barbosa CS, Brémond P, Canese AP, de Souza CP, Dominguez C, File S, Gutierrez A, Incani RN, Kawano T, Kazibwe F, Kpikpi J, Lwambo NJS, Mimpfoundi R, Njiokou F, Poda JN, Sene M, Velásquez LE, Yong M, Adema CM, Hofkin BV, Mkoji GM and Loker ES (2001) Evolutionary relationships and biogeography of Biomphalaria (Gastropoda: Planorbidae) with implications regarding its role as host of the human bloodfluke, Schistosoma mansoni. Molecular Biology and Evolution 18:2225-2239.
24) Zhang S-M, Léonard PM, Adema CM, Loker ES (2001) Parasite responsive IgSF members in the snail Biomphalaria glabrata: characterization of novel genes with tandemly arranged IgSF domains and a fibrinogen domain. Immunogenetics. 53:684-694.
25) Adema CM (2002) Comparative study of cytoplasmic actin DNA from six species of Planorbidae (Gastropoda: Basommatophora). Journal of Molluscan Studies 68:17-23.
26) Horak P, Kolarova L, Adema CM (2002) Biology of the schistosome genus Trichobilharzia. Advances in Parasitology 52:155-233.
27) Loker ES, Adema CM, Zhang S-M, Kepler TB (2004) Invertebrate immune systems – not homogeneous, not simple, not well understood. Immunological Reviews 198:10-24.
28) Zhang S-M, Adema CM, Kepler TB, Loker ES (2004) Diversification of Ig superfamily genes in an invertebrate. Science 305:251-254.
29) DeJong RJ, Emery A, Adema CM (2004) The mitochondrial genome of Biomphalaria glabrata (Gastropoda: Bassomatophora), intermediate host of Schistosoma mansoni. Journal of Parasitology 90:991-996.
30) Nowak S, Woodards A, Jung Y, Adema CM, Loker (2004) Expressed sequence tags (ESTs) differentially expressed during the internal defense response to Schistosoma mansoni of a resistant strain of Biomphalaria glabrata. Journal of Parasitology 90:1034-1041.
31) Hertel LA, Adema CM, Loker ES (2005) Differential expression of FREP genes in two strains of Biomphalaria glabrata following exposure to the digenetic trematodes Schistosoma mansoni and Echinostoma paraensei. Developmental and Comparative Immunology 29:295-303.
32) Qiu S, Adema CM, Lane T (2005) A computational study of off-target effects of RNA-interference. Nucleic Acids Research 33:1834-1847.
33) Jung Y, Nowak S, Hertel LA, Zhang S-M, Loker ES, Adema CM (2005) Manganese superoxide dismutase from Biomphalaria glabrata. Journal of Invertebrate Pathology 90:59-63.
34) Lieb B, Dimitrova K, Kang HS, Braun S, Gebauer W, Martin A, Hanelt B, Saenz SA, Adema CM, Markl J (2006) Red blood with blue-blood ancestry: intriguing structure of a snail hemoglobin. Proceedings of the National Academy of Sciences USA 103:12011-12016. (Epub 2006 Jul 28). PMID: 16877545 PMCID: PMC1567689
35) Adema CM, Luo M-Z, Hanelt B, Hertel LA, Marshall JJ, Zhang S-M, DeJong RJ, Kim H-R, Kudrna D, Wing RA, Soderlund C, Knight M, Lewis FA, Caldeira RL, Jannotti-Passos LK, Carvalho OS, Loker ES (2006) A BAC library for Biomphalaria glabrata, intermediate snail host of Schistosoma mansoni. Memorias do Instituto Oswaldo Cruz 101:167-177. PMID: 17308766
36) Hanelt B, Lun C-M, Adema, CM (2008) Comparative ORESTES-sampling of transcriptomes of immune-challenged Biomphalaria glabrata snails. Journal of Invertebrate Pathology, 99, 192-203. PMID 18590737.
37) Coustau C, Gourbal B, Mitta G, Adema CM. (2008). Echinostomes and snails: exploring complex interactions. Chapter 2 in: The Biology of Echinostomes (Fried B and Toledo R, eds.), New York: Springer. 35-60.
38) Stout BA, Adema CM, Zhang S-M, Loker ES (2009) The biology of FREPs: diversified lectins with fibrinogen-related domains from the freshwater snail Biomphalaria glabrata. In Animal Lectins: A Functional View. Eds: G. Vasta & H. Ahmed. CRC Press Taylor & Francis. pp 475-491.
39) Adema CM, Lun C-M , Hanelt B, Seville RS (2009) Digenean trematode infections of native fresh water snails and invasive Potamopyrgus antipodarum in the Grand Teton National Park/John D Rockefeller Memorial Parkway Area. Journal of Parasitology, 95, 224-227. PMID 18576875.
40) Zhang S-M, Nian H, Wang B, Loker ES, Adema CM (2009) Schistosomin from the snail Biomphalaria glabrata: Expression studies suggest no involvement in trematode-mediated castration. Molecular and Biochemical Parasitology. 165, 79-86. PMID: 19393164
41) Adema CM, Hanington PC, Lun CM, Rosenberg GH, Aragon AD, Stout BA, Lennard-Richard ML, Gross PS, Loker ES (2010) Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes). Molecular Immunology 47, 849-860, Epub ahead of print 2009 Dec 2. doi:10.1016/j.molimm.2009.10.019 PMID: 19962194
42) Hathaway JJ, Adema CM, Stout BA, Mobarak CD, Loker ES (2010) Identification of protein components of egg masses indicates parental investment in immunoprotection of offspring by Biomphalaria glabrata (Gastropoda, Mollusca). Dev Comp Immunol. 34, 425–435. Epub ahead of print 2009 Dec 14. doi:10.1016/j.dci.2009.12.001 PMID: 19995576, PMCID: PMC2813990.
43) Hanington PC, Lun CM, Adema CM, Loker ES (2010) Time series analysis of the transcriptional responses of Biomphalaria glabrata throughout the course of intramolluscan development of Schistosoma mansoni and Echinostoma paraensei.Int J Parasitol. 40, 819-831. Epub ahead of print 2010 Jan 15. doi:10.1016/j.ijpara.2009.12.005 PMID: 20083115
44) Hanington PC, Forys MA, Dragoo JW, Zhang S-M, Adema CM, Loker ES (2010) A role for a somatically diversified lectin in resistance of an invertebrate to parasite infection. Proceedings of the National Academy of Science USA, 49: 21087-21092, [Epub ahead of print] doi: 10.1073/pnas.1011242107. PMID: 21084634, PMCID:PMC3000291
45) Knight M, Ittiprasert W, Odoemelam EC, Adema CM, Miller A, Raghavana N, Bridger JM (2011) Non-random organization of the Biomphalaria glabrata genome in interphase Bge cells and the spatial repositioning of activated genes in cells co-cultured with Schistosoma mansoni. International Journal for Parasitology 41:61-70. [Epub ahead of print] doi:10.1016/j.ijpara.2010.07.015. PMID: 20849859.
46) Mitta G, Adema CM, Gourbal B, Loker ES, Theron A. (2012) Compatibility polymorphism in snail/schistosome interactions: from field to theory to molecular mechanisms. Developmental and Comparative Immunology 37, 1-8 [Epub ahead of print] PMID: 21945832.
47) Van Horn DJ, Hall JR, Loker ES, Mitchell KR, Mkoji GM, Adema CM, Takacs-Vesbach CD (2012) Complex intestinal bacterial communities in three species of planorbid snails. Journal of Molluscan Studies 78:74-80. published online October 11, 2011 doi:10.1093/mollus/eyr038.
48) Lockyer AE, Emery AM, Kane RA, Walker AJ, Mayer CD, Mitta G, Coustau C, Adema CM, Hanelt B, Rollinson D, Noble LR, Jones CS (2012). Identification of an early differential response to Schistosoma mansoni infection in haemocytes from schistosome-resistant and -susceptible Biomphalaria glabrata strains using cDNA microarrays. PLOS ONE, 7:12, e51101.
49) Adema CM, Bayne CJ, Bridger JM, Knight M, Loker ES, Yoshino TP, Zhang S-M. (2012) Editorial Will all scientists working on snails and the diseases they transmit please stand up? PLOS-Neglected Tropical Diseases, 6:12, e1835.
50) Fneich S, Dheilly N, Adema CM, Rognon A, Reichelt M, Bulla J, Grunau C, Cosseau C (2013) 5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni. Parasites & Vectors 06/2013; 6(1):167
51) Kraus TJ, Brant SV, Adema CM (2014) Characterization of trematode cercariae from Physella acuta in the Middle Rio Grande. Comparative Parasitology, Comparative Parasitology, 81(1),105–109. doi: http://dx.doi.org/10.1654/4674.1.
52) Dheilly N, Adema CM, Raftos DA, Grunau C, Du Pasquier L (2014) No more non-model species: the promise of next generation sequencing for comparative immunology. Developmental and Comparative Immunology. 45:56-66. doi: 10.1016/j.dci.2014.01.022. PMID: 24508980
53) Nolan JR, Bergthorsson U, Adema CM (2014) Physella acuta: atypical gene order among mitochondrial genomes of Panpulmonata. Journal of Molluscan Studies, doi:10.1093/mollus/eyu025. PMID: 25368439
54) Dheilly NM, Duval D, Mouahid G, Emans R, Allienne J-F, Galinier R, Genthon C, Dubois E, Du Pasquier L, Adema CM, Grunau C, Mitta G, Gourbal B (2015) A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata . Developmental and Comparative Immunology. 48:234–243. doi.org/10.1016/j.dci.2014.10.009. PMID: 25451302
55) Adema CM, Loker ES (2015) Digenean-gastropod host associations reveal foundations of specific immunity in snails. Developmental and Comparative Immunology, 48 pp. 275-283: doi:10.1016/j.dci.2014.06.014. PMID: 25034871.
56) Coustau C, Gourbal B, Duval D, Yoshino TP, Adema CM, Mitta G (2015) Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade. Fish and Shellfish Immunology 46, 5-16. doi: 10.1016/j.fsi.2015.01.036. PMID: 25662712.
57) Zhang S-M, Buddenborg SK, Adema CM, Sullivan JT, Loker ES (2015) Altered gene expression in the schistosome-transmitting snail Biomphalaria glabrata following exposure to niclosamide, the active ingredient in the widely used molluscicide Bayluscide. PLOS-Neglected Tropical Diseases. doi:10.1371/journal.pntd.0004131 PMID:26452273, PMC4599737
58) Adema CM (2015) Fibrinogen-related proteins (FREPs) in mollusks. Chapter 6 Pathogen-Host Interactions: antigenic variation v. somatic adaptations. (Hsu E and DuPasquier L, eds), New York: Springer. 111-130. doi: 10.1007/978-3-319-20819-0. PMID:265373797
59) McLean N, Newkirk K, Adema CM (2016) Canine ocular onchocerciasis: a retrospective review of the diagnosis, treatment and outcome of 16 cases in New Mexico (2011-2015). Veterinary Ophthalmology doi: 10.1111/vop.12433. PMID:27624855.
60) Pena JJ, Adema CM (2016) The planorbid snail Biomphalaria glabrata expresses a hemocyanin-like sequence in the albumen gland. PLoS ONE 11(12): e0168665. doi:10.1371/journal.pone.0168665. PMID: 28036345.62) Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, Oliveira , Raghavan N, Shedlock A, Amaral LR do, Arican-Goktas HD, Assis J, Baba EH, Baron OL, Bayne CJ, Bickham-Wright U, Biggar KK, Blouin M, Bonning BC, Botka C, Bridger JM, Buckley KM, Buddenborg SK, Caldeira RL, Carleton J, Carvalho OS, Castillo MG, Chalmers IW, Christensens M, Clifton S, Cosseau C, Coustau C, Cripps RM, Cuesta-Astroz Y, Cummins S, diStephano L, Dinguirard N, Duval D, Emrich S, Feschotte C, Feyereisen R, FitzGerald P, Fronick C, Fulton L, Galinier R, Geusz M, Geyer KK, Giraldo-Calderon G, Gomes de Souza M, Gordy MA, Gourbal B, Grossi S, Grunau C, Hanington PC, Hoffmann KF, Hughes D, Humphries J, Izinara R, Jackson DJ, Jannotti-Passos LK, Jeremias de Jesus W, Jobling S, Kamel B, Kapusta A, Kaur S, Koene JM, Kohn AB, Lawson D, Lawton SP, Liang D, Limpanont Y, Lockyer AE, Lovato TL, Liu S, Magrini V, McManus DP, Medina M, Misra M, Mitta G, Mkoji GM, Montague MJ, Montelongo C, Moroz LL, Munoz-Torres MC, Niazi U, Noble LR, Pais F, Papenfuss AT, Peace R, Pena JJ: Pila EA, Quelais T, Raney BJ, Rast JP, Ribeiro F, Rollinson D, Rotgans B, Routledge EJ, Ryan KM, Scholte L, Silva F, Storey KB, Swain M, Tennessen JA, Tomlinson C, Trujillo DL, Volpi EV, Walker AJ, Wang T, Wannaporn I, Warren WC, Wu X-J, Yoshino TP, Yusuf M, Zhang S-M, Zhao M, Wilson R (2017) Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications 8, 15451 doi: 10.1038/ncomms15451. PMCID: PMC5440852
63) Schultz JH, Bu L, Adema CM (2018) Comparative immunological study of the snail Physella acuta (Hygrophila, Pulmonata) reveals shared and unique aspects of gastropod immunobiology. Molecular Immunology 101, 108-119. DOI: 10.1016/j.molimm.2018.05.029 PMID: 29920433
64) Schultz JHG, Bansbach LMG, Bremmer JAU, Dimmler KEU, Forde QAU, Gagliano EMU, Glenn EMG, Greengrass CMU, Hayes JPU, Kraus ALG, Larsen LIU, Lucero EU, McClendon MTU, Mercer HLG, Mims KCU, Patel KNU, Patsalis FIU, Peterson DEG, Platero JMU, Rizvi MMU, Serna KIU, Steele TEU, Turner NLU, Bu L, Lu LG, Adema CM (2018) The mitochondrial genome of the planorbid snail Planorbella duryi. Mitochondrial DNA Part B: Resources, doi: 10.1080/23802359.2018.1503939. (U undergraduate, G graduate)
65)Schultz JH, Bu L, Kamel B, Adema CM (201n) RNA-SEQ: the early response of the snail Physella acuta to the digenetic trematode Echinostoma paraensei. Journal of Parasitology in revision
Miscellaneous
1) Adema CM, Knight M, Lewis FA, Loker ES (2002) Request for making
a BAC library from Biomphalaria glabrata (gastropod mollusc), the prominent
snail species contributing to transmission of human schistosomiasis. In July
2002, review of this white paper by the Genome Resources and Sequencing Priorities
Panel (GRASPP) of the NHGRI (National Human Genome Research Institute) BAC Resource
Steering Panel yielded a "high priority" recommendation. In cooperation with
the NIH BAC resources program, a BAC library was produced that is now available
to the research community.
2) Knight M, Adema CM, Raghavan N, Loker ES, Lewis FA, Tettelin H (2003) Obtaining the genome sequence of the mollusc Biomphalaria glabrata: a major intermediate host for the parasite causing human schistosomiasis. In July 2004, review of this white paper resulted in the addition of B. glabrata to the genome sequencing pipeline of NHGRI ("high priority" recommendation)