ATP-PC
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Course Outline
Lecture Notes
Readings

Phosphagen Energy System, 31P MRS and Purine Nucleotide Cycle

a) Classic Studies

Harris RC. Et al. The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man. Pfluegers Arch. 1977 367:137-142.

Sapega et al. Phosphorus nuclear magnetic resonance: a non-invasive technique for the study of muscle bioenergetics during exercise. Med Sci Sports Exerc. 1987 19(4):410-420.

Tesch P.A. et al. Creatine phosphate in fiber types of skeletal muscle before and after exhaustive exercise. J Appl Physiol. 1989 66(4):1756-1759.

Veech R.L. et al. Cytosolic phosphorylation potential. J Biol Chem. 1979 254(14):6538-6547.

b) Recent Research

Bangsbo J. et al. NMR and analytic biochemical evaluation of CrP and nucleotides in the human calf during muscle contraction. J Appl Physiol. 1993 74(4):2034-2039.

Barbiroli B, Iotti S, Lodi R. Aspects of human bioenergetics as studied in vivo by magnetic resonance spectroscopy. Biochimie. 1998 Oct;80(10):847-53.

Binzoni T, Hiltbrand E, Yano T, Cerretelli P. Step vs. progressive exercise: the kinetics of phosphocreatine hydrolysis in human muscle. Acta Physiol Scand. 1997 Mar;159(3):209-15.

Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK. Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated sprint exercise. J Appl Physiol. 1996 Mar;80(3):876-84.

Boska MD, Nelson JA, Sripathi N, Pipinos II, Shepard AD, Welch KM. 31P MRS studies of exercising human muscle at high temporal resolution. Magn Reson Med. 1999 Jun;41(6):1145-51.

Febbraio MA, Flanagan TR, Snow RJ, Zhao S, Carey MF. Effect of creatine supplementation on intramuscular TCr, metabolism and performance during intermittent, supramaximal exercise in humans. Acta Physiol Scand. 1995 Dec;155(4):387-95.

Francaux M, Demeure R, Goudemant JF, Poortmans JR. Effect of exogenous creatine supplementation on muscle PCr metabolism. Int J Sports Med. 2000 Feb;21(2):139-45.

Guthrie BM, Frostick SP, Goodman J, Mikulis DJ, Plyley MJ, Marshall KW. Endurance-trained and untrained skeletal muscle bioenergetics observed with magnetic resonance spectroscopy. Can J Appl Physiol. 1996 Aug;21(4):251-63.

Haseler LJ, Hogan MC, Richardson RS. Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability. J Appl Physiol. 1999 Jun;86(6):2013-8.

Haseler LJ, Richardson RS, Videen JS, Hogan MC. Phosphocreatine hydrolysis during submaximal exercise: the effect of FIO2. J Appl Physiol. 1998 Oct;85(4):1457-63.

Hellsten Y, Richter EA, Kiens B, Bangsbo J. AMP deamination and purine exchange in human skeletal muscle during and after intense exercise. J Physiol. 1999 Nov 1;520 Pt 3:909-20.

Hogan MC, Richardson RS, Haseler LJ. Human muscle performance and PCr hydrolysis with varied inspired oxygen fractions: a 31P-MRS study. J Appl Physiol. 1999 Apr;86(4):1367-73.

McKenna MJ, Morton J, Selig SE, Snow RJ. Creatine supplementation increases muscle total creatine but not maximal intermittent exercise performance. J Appl Physiol. 1999 Dec;87(6):2244-52.

Nevill AM, Jones DA, McIntyre D, Bogdanis GC, Nevill ME. A model for phosphocreatine resynthesis. J Appl Physiol. 1997 Jan;82(1):329-35.

Rico-Sanz J. Creatine reduces human muscle PCr and pH decrements and P(i) accumulation during low-intensity exercise. J Appl Physiol. 2000 Apr;88(4):1181-91.

Robinson TM, Sewell DA, Hultman E, Greenhaff PL. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J Appl Physiol. 1999 Aug;87(2):598-604.

Roussel M, Bendahan D, Mattei JP, Le Fur Y, Cozzone PJ. 31P magnetic resonance spectroscopy study of phosphocreatine recovery kinetics in skeletal muscle: the issue of intersubject variability. Biochim Biophys Acta. 2000 Feb 24;1457(1-2):18-26.

Trump ME, Heigenhauser GJ, Putman CT, Spriet LL. Importance of muscle phosphocreatine during intermittent maximal cycling. J Appl Physiol. 1996 May;80(5):1574-80.

Vanderthommen M, Gilles R, Carlier P, Ciancabilla F, Zahlan O, Sluse F, Crielaard JM. Human muscle energetics during voluntary and electrically induced isometric contractions as measured by 31P NMR spectroscopy. Int J Sports Med. 1999 Jul;20(5):279-83.

Wackerhage H, Hoffmann U, Essfeld D, Leyk D, Mueller K, Zange J. Recovery of free ADP, Pi, and free energy of ATP hydrolysis in human skeletal muscle. J Appl Physiol. 1998 Dec;85(6):2140-5.

Whipp BJ, Rossiter HB, Ward SA, Avery D, Doyle VL, Howe FA, Griffiths JR. Simultaneous determination of muscle 31P and O2 uptake kinetics during whole body NMR spectroscopy. J Appl Physiol. 1999 Feb;86(2):742-7.