Lactate/Acidosis
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Course Outline
Lecture Notes
Readings

Muscle Redox

a) Classic Studies

Denis C, Dormois D, Linossier MT, Geyssant A, Lacour JR. Total muscle NADH during 30-min submaximal exercise: effects of endurance training. Acta Physiol Scand. 1991 Jun;142(2):301-2.

Graham T, Sjogaard G, Lollgen H, Saltin B. NAD in muscle of man at rest and during exercise. Pflugers Arch. 1978 Aug 25;376(1):35-9.

Katz A, Sahlin K. Effect of decreased oxygen availability on NADH and lactate contents in human skeletal muscle during exercise. Acta Physiol Scand. 1987 Sep;131(1):119-27.

Ren JM, Henriksson J, Katz A, Sahlin K. NADH content in type I and type II human muscle fibres after dynamic exercise. Biochem J. 1988 Apr 1;251(1):183-7.

Sahlin K, Katz A, Henriksson J. Redox state and lactate accumulation in human skeletal muscle during dynamic exercise. Biochem J. 1987 Jul 15;245(2):551-6.

Sahlin K. NADH in human skeletal muscle during short-term intense exercise. Pflugers Arch. 1985 Feb;403(2):193-6.

Lactate Kinetics

a) Classic Studies

Chwalbinska-Moneta J. et al. Threshold for muscle lactate accumulation during progressive exercise. J Appl Physiol. 1989 66(6):2710-2716.

Katz A, Sahlin K. Regulation of lactic acid production during exercise. J Appl Physiol. 1988 Aug;65(2):509-18. Review.

Sahlin K, Harris RC, Nylind B, Hultman E. Lactate content and pH in muscle obtained after dynamic exercise. Pflugers Arch. 1976 Dec 28;367(2):143-9.

b) Recent Research

Brooks GA. Intra- and extra-cellular lactate shuttles. Med Sci Sports Exerc. 2000 Apr;32(4):790-9.

Gladden LB. Muscle as a consumer of lactate. Med Sci Sports Exerc. 2000 Apr;32(4):764-71.

Heigenhauser GJ, Parolin ML. Role of pyruvate dehydrogenase in lactate production in exercising human skeletal muscle. Adv Exp Med Biol. 1999;474:205-18.

Howlett RA, Heigenhauser GJ, Spriet LL. Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion. J Appl Physiol. 1999 Nov;87(5):1747-51.

Richardson RS, Noyszewski EA, Leigh JS, Wagner PD. Lactate efflux from exercising human skeletal muscle: role of intracellular PO2. J Appl Physiol. 1998 Aug;85(2):627-34.

Wasserman K. Critical capillary PO2 and the role of lactate production in oxyhemoglobin dissociation during exercise. Adv Exp Med Biol. 1999;471:321-33.

Grassi B, Quaresima V, Marconi C, Ferrari M, Cerretelli P. Blood lactate accumulation and muscle deoxygenation during incremental exercise. J Appl Physiol. 1999 Jul;87(1):348-55.

Bogdanis GC, Nevill ME, Lakomy HK, Boobis LH. Power output and muscle metabolism during and following recovery from 10 and 20 s of maximal sprint exercise in humans. Acta Physiol Scand. 1998 Jul;163(3):261-72.

Chin ER, Lindinger MI, Heigenhauser GJ. Distribution of lactate and other ions in inactive skeletal muscle: influence of hyperkalemic lactacidosis. Can J Physiol Pharmacol. 1997 Dec;75(12):1375-86.

Myers J, Ashley E. Dangerous curves. A perspective on exercise, lactate, and the anaerobic threshold. Chest. 1997 Mar;111(3):787-95.

Riley M, Maehara K, Porszasz J, Engelen MP, Bartstow TJ, Tanaka H, Wasserman K. Association between the anaerobic threshold and the break-point in the double product/work rate relationship. Eur J Appl Physiol Occup Physiol. 1997;75(1):14-21.

Belardinelli R, Barstow TJ, Porszasz J, Wasserman K. Skeletal muscle oxygenation during constant work rate exercise. Med Sci Sports Exerc. 1995 Apr;27(4):512-9.

Juel C. Lactate/proton co-transport in skeletal muscle: regulation and importance for pH homeostasis. Acta Physiol Scand. 1996 Mar;156(3):369-74.

Poole RC, Halestrap AP. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol. 1993 Apr;264(4 Pt 1):C761-82.

Bonen A. Lactate transporters (MCT proteins) in heart and skeletal muscles. Med Sci Sports Exerc. 2000 Apr;32(4):778-89.

Bonen A, Baker SK, Hatta H. Lactate transport and lactate transporters in skeletal muscle. Can J Appl Physiol. 1997 Dec;22(6):531-52.

Acidosis

a) Classic Studies

Sahlin K, Harris RC, Nylind B, Hultman E. Lactate content and pH in muscle obtained after dynamic exercise. Pflugers Arch. 1976 Dec 28;367(2):143-9.

Spriet LL. Et al. Skeletal muscle glycogenolysis, glycolysis, and pH during electrical stimulation in men. J Appl Physiol. 1987 62(2):616-621.

b)Recent Research

Bangsbo J, Aagaard T, Olsen M, Kiens B, Turcotte LP, Richter EA. Lactate and H+ uptake in inactive muscles during intense exercise in man. J Physiol. 1995 Oct 1;488 ( Pt 1):219-29.

Chuang ML, Ting H, Otsuka T, Sun XG, Chiu FY, Beaver WL, Hansen JE, Lewis DA, Wasserman K. Aerobically generated CO(2) stored during early exercise. J Appl Physiol. 1999 Sep;87(3):1048-58.

Hollidge-Horvat MG, Parolin ML, Wong D, Jones NL, Heigenhauser GJ. Effect of induced metabolic alkalosis on human skeletal muscle metabolism during exercise. Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E316-29.

Juel C. Lactate-proton cotransport in skeletal muscle. Physiol Rev. 1997 Apr;77(2):321-58.

Juel C. Muscle pH regulation: role of training. Acta Physiol Scand. 1998 Mar;162(3):359-66.

Kemp GJ, Thompson CH, Taylor DJ, Radda GK. Proton efflux in human skeletal muscle during recovery from exercise. Eur J Appl Physiol Occup Physiol. 1997;76(5):462-71.

Kowalchuk JM, Scheuermann BW. Acid-base balance: origin of plasma [H+] during exercise. Can J Appl Physiol. 1995 Sep;20(3):341-56.

Lindinger MI. Origins of [H+] changes in exercising skeletal muscle. Can J Appl Physiol. 1995 Sep;20(3):357-68.

Lodi R, Kemp GJ, Iotti S, Radda GK, Barbiroli B. Influence of cytosolic pH on in vivo assessment of human muscle mitochondrial respiration by phosphorus magnetic resonance spectroscopy. MAGMA. 1997 Jun;5(2):165-71.

Mannion AF, Jakeman PM, Willan PL. Skeletal muscle buffer value, fibre type distribution and high intensity exercise performance in man. Exp Physiol. 1995 Jan;80(1):89-101.

Medbo JI, Hanem S, Noddeland H, Jebens E. Arterio-venous differences of blood acid-base status and plasma sodium caused by intense bicycling. Acta Physiol Scand. 2000 Feb;168(2):311-26.

Pilegaard H, Domino K, Noland T, Juel C, Hellsten Y, Halestrap AP, Bangsbo J. Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle. Am J Physiol. 1999 Feb;276(2 Pt 1):E255-61.

Scheuermann BW, Kowalchuk JM, Paterson DH, Taylor AW, Green HJ. Muscle metabolism during heavy-intensity exercise after acute acetazolamide administration. J Appl Physiol. 2000 Feb;88(2):722-9.

Sullivan MJ, Saltin B, Negro-Vilar R, Duscha BD, Charles HC. Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men. J Appl Physiol. 1994 Nov;77(5):2194-200.

Weston AR, Myburgh KH, Lindsay FH, Dennis SC, Noakes TD, Hawley JA. Skeletal muscle buffering capacity and endurance performance after high-intensity interval training by well-trained cyclists. Eur J Appl Physiol Occup Physiol. 1997;75(1):7-13.